Simplified Method in Polynucleotide Helix-Coil Transition Theory Including Binding of Complementary Monomer
نویسندگان
چکیده
منابع مشابه
Simplified method in polynucleotide helix-coil transition theory including binding of complementary monomer.
The grand partition function for a long linear system of alternating alpha and beta sequences with the restraint of a fixed number, N(alphabeta), of alphabeta boundaries depends in an extremely simple way on the alpha-sequence and beta-sequence grand partition functions, xi(alpha) and xi(beta). When the restraint is removed, we have mualphabeta = 0, where mualphabeta is the chemical potential c...
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A simplified model for the closed circular DNA (ccDNA) is proposed to describe some specific features of the helix-coil transition in such molecule. The Hamiltonian of ccDNA is related to the one introduced earlier for the linear DNA. The basic assumption is that the reduced energy of the hydrogen bond is not constant through the transition process but depends effectively on the fraction of alr...
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Based on the Zimm-Bragg model we study cooperative helix-coil transition driven by a finite-speed change of temperature. There is an asymmetry between the coil→helix and helix→coil transition: the latter is displayed already for finite speeds, and takes shorter time than the former. This hysteresis effect has been observed experimentally, and it is explained here via quantifying system’s stabil...
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We discuss the effects of the solvent composition on the helix-coil transition of a polypeptide chain. We use a simple model to demonstrate that improving the hydrogen-bonding ability of the solvent can make the transition less cooperative, without affecting the transition temperature. This effect is very different from other solvent effects which primarily influence the melting transition rath...
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We analyze the problem of the helix-coil transition in explicit solvents analytically by using spin-based models incorporating two different mechanisms of solvent action: explicit solvent action through the formation of solvent-polymer hydrogen bonds that can compete with the intrinsic intra-polymer hydrogen bonded configurations (competing interactions) and implicit solvent action, where the s...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1972
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.69.5.1165